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Application of this model could potentially lead to pioneering strategies to counteract or treat age-related muscle atrophy and impaired regeneration with fibrosis and fat infiltration (including sarcopenia and frailty).

Its production and recycling depend on protein intake, amino-acid availability, selenium, magnesium, B vitamins, metabolic health, liver function and the bodys overall oxidative burden

Among the compounds synthesized, we highlight compounds 7 (IC 50 = 0.084 M), 8 (IC 50 = 0.102 M), and 9 (IC50 = 0.064 M), which are good inhibitors and meet the criteria of Lipinski's rules for oral administration as drugs (Figure 6)

doi: 10.3389/fphar.2018.01120