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Dihexa, also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is a neuroregenerative peptide that has shown remarkable potential in promoting synaptic plasticity and neuronal survival

In 1679, Antonie van Leeuwenhoek, a pioneer in microbiology, first observed crystals from tophi in gout patients

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Overall, most of the studies identified were conducted individually in continental countries such as Brazil, Chile, Argentina, Mxico, Ecuador and Colombia, which have a lower proportion of African ancestry compared to island nations like Haiti or The Bahamas ( Figure 1 )