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Similar content being viewed by others Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RA) like samaglutide and Terzipatide, are widely utilized for the treatment of type 2 diabetes mellitus and obesity due to its proven efficacy in glucose regulation, weight loss, and cardiovascular protection [1, 2]

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For a patient who has hit a significant plateau, the logic is that phentermine can provide the immediate appetite suppression and energy boost needed to break through, while the semaglutide provides the long-term satiety and metabolic regulation required for sustainability

Metabolite interaction network was strongly affected by GCK which is the 3 rd interactor in GLP1R interactome (Fig