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Generally, deep metabolic modulators are utilized in specific, controlled cycles rather than completely indefinitely

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Superimposing the structures of GCGRG s bound by GCG 4 , peptide 15 (GLP-1R and GCGR dual agonist) 24 and peptide 20 reveals that these three peptides adopt a similar binding pose: a single continuous helix that penetrates into the TMD core through their N-terminal halves (residues 1 to 15), while the C-terminal halves (residues 16 to 30) are recognized by the ECD, ECL1 and TM1 (Fig