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The observed changes at both the SDL and coils/turns of the -propeller could, therefore, result in functional alteration in ligand-binding affinity at the RGD-binding site (i.e., site I), leading to binding of v3 integrin-specific extracellular matrix (ECM) ligands to site I

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International Journal of Molecular Sciences (2021) This study examined how Semax alters brain protein expression following transient middle cerebral artery occlusion (ischemia-reperfusion) in rats, using real-time RT-PCR and immunodetection to measure a targeted panel of proteins involved in inflammation, cell death, and neuroprotection