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In addition to small-molecular antioxidants, extracellular antioxidant defense against ROS is also mediated by SOD mimetic compounds, capable of scavenging superoxide radicals and preventing the formation of damaging peroxynitrite, formed by the reaction between superoxide and nitric oxide
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In yeast, Ohsumis and Klionskys laboratories first identified that ATG32 acts as the mitophagy-specific receptor, which directly interacts with the selective autophagy adaptor ATG8 via an ATG8-interacting motif (AIM) and ATG11 to form the nascent autophagosome (Kanki et al., 2009
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