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However, adverse effects may limit the treatment potential, e.g., glitazones are associated with phenotypical weight gain [136] and obeticholic acid induced pruritus and elevated LDL-C [137], the latter a potential concern in patients already at risk for cardiovascular disease

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If an NSAID doesnt provide enough relief, or if side effects become problematic, your doctor may prescribe a drug belonging to a category called tumor necrosis factor (TNF) alpha-blockers