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Exploring how microgravity disrupts the interaction between lysosomes and mitochondria may be especially relevant for certain lysosomal disorders, such as mucolipidosis and Fabry disease, where combined organelle dysfunction has been reported 19,20,28

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Enhancement in ROS intensities in the damaged cells leads to alteration in the structure and properties of amino acids, extreme cross-linking, breakdown of the peptide chains, change in electric charge and enhances protein degradation susceptibility [121]

However, the situation is different in major bustling cities like Tehran