The research spans decades and multiple disease models, from animal studies showing dramatic reductions in disease markers to early clinical trials in humans yielding cautious optimism
Modern therapies for the treatment of type 2 diabetes, such as glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 (SGLT-2) inhibitors, have consistently demonstrated efficacy in terms of reducing glycated hemoglobin (HbA1c) levels and body weight, while offering minimal risk of hypoglycemia
Rationale for the Recommendation Semaglutide (Wegovy) was reviewed by CDEC in October 2022 for the indication as an adjunct to a reduced calorie diet and increased physical activity for chronic weight management in adult patients with an initial body mass index of 30 kg/m 2 or greater (obesity), or 27 kg/m 2 or greater (overweight) in the presence of at least 1 weight-related comorbidity such as hypertension, type 2 diabetes mellitus (T2DM), dyslipidemia, or obstructive sleep apnea and was not recommended for reimbursement
Good candidates for bariatric surgery are those with a body mass index (BMI) over 40, or between 35 and 40 with additional weight-related health issues like type 2 diabetes