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GLP-1 RAs augment insulin secretion after meals and inhibit glucagon production from pancreatic alpha cells at hyper- or euglycemia

The exact ingredients can vary between brands, but GLP-1 patches typically contain a combination of natural extracts and vitamins , like: berberine (the main active ingredient, thought to support GLP-1 release) green tea extract cinnamon extract mint pomegranate extract a selection of vitamins None of these are clinically approved for weight loss , and the amounts absorbed through the skin are not well studied or proven to be effective

Because it affects multiple hormone receptors, retatrutide dosing must be carefully managed

Key Takeaways GLP-1 drugs mimic a hormone your body already makes to suppress appetite and regulate blood sugar