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Researchers should exercise extreme caution and prioritize foundational studies to build an evidence base for such combinations

Relevant UK guidance includes: NICE Technology Appraisal for semaglutide (Wegovy) in weight management sets out the criteria for use and monitoring in adults with obesity [4] [5] NICE guideline NG28: Type 2 diabetes in adults: management covers the use of incretin-based therapies in type 2 diabetes [6] NICE Technology Appraisal for tirzepatide (Mounjaro) in type 2 diabetes confirms the scope of UK recommendations for tirzepatide [7] [8] Your prescriber can help assess whether your symptoms are expected, manageable, or warrant a change in treatment

Supporting this idea is the fact that several incretin agonists like semaglutide and liraglutide have been linked to improvements in heart health among people with diabetes

It doesn't induce or inhibit the cytochrome P450 enzymes that metabolize estrogen and progestin