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Rotondi et al., 2015

Dosing frequency comparison The frequency differences are dramatic: Oral semaglutide tablets: Once daily Sublingual semaglutide drops: Once daily (potentially three times weekly at maintenance) Injectable semaglutide (Ozempic/Wegovy): Once weekly Injectable tirzepatide (Mounjaro/Zepbound): Once weekly Injectable liraglutide (Saxenda): Once daily The semaglutide vs tirzepatide comparison covers effectiveness differences between these two primary GLP-1 medications regardless of delivery method

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