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Although AD and VaD share common vascular risk factors, the contribution of small artery disease to VaD pathogenesis may be greater than that of AD [120].In fact, studies have found that neuropathic changes can be evident 20 years before the onset of dementia and that there is a substantial neuronal loss in the MCI stage, which is considered a transitional state before the onset of dementia [121]

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In addition , pharmacological testing revealed that AC caused a dose-dependent reduction in systolic, diastolic, and mean arterial blood pressure in pentothal-anesthetized normotensive rats (Ahmad et al