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Outcome Primary: Cardiovascular outcomes - major adverse cardiovascular events [MACE]

Enhanced expression of GSH metabolism enzymes including glutathione peroxidases, gamma-glutamyl cysteinyl synthetase (gamma-GCS), glutathione S-transferases (GST), and ABC-family membrane transport proteins including the multidrug resistance-associated protein (MRP) were all documented to play prominent roles in cellular resistance to oxidative stress

Methylene blue (MeBl) was first noted as a potential therapy for dementia when it was dropped on an Alzheimer's tissue sample and found to help dissolve fibrillary tangles and amyloid plaques associated with the disease

MAIN FUNCTION OF CARNITINE The well-documented role of carnitine is in the facilitation of the transport of long-chain fatty acids into the matrix of mitochondria, where it undergoes beta-oxidation to produce energy