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In large randomized controlled trials, patients receiving semaglutide 2.4 mg lost a mean of 6% of their weight by week 12 and 12% of their weight by week 28, Wissam Ghusn, MD, postdoctoral research fellow from the division of gastroenterology and hepatology of the Precision Medicine for Obesity Laboratory at Mayo Clinic in Rochester, Minnesota, and colleagues wrote

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But doctors have said that they are noticing an unusual thing in people on the medication, though unlike others this is not caused directly by the GLP-1 medication, but by the rapid weight loss it helps to bring about

pubmed.ncbi.nlm.nih.gov/15856065