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Whether treatment should be ended, paused, or adjusted depends, among other things, on tolerability, treatment goals, comorbidities, and the original reason for use

These include pancreatitis, vision problems like NAION or worsening diabetic retinopathy, low blood sugar when taken with insulin or sulfonylureas, acute kidney injury, severe digestive issues such as gastroparesis or ileus, allergic reactions, gallbladder disease and a higher risk of aspiration during surgery because Ozempic slows digestion

Current evidence does not suggest that semaglutide directly promotes muscle catabolism through its pharmacological action