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Funding: This work was supported by grants from the Science and Technology Innovation 2030-Major Project of the Ministry of Science and Technology of China, the National Natural Science Foundation of Distinguished Young Scholars, the National Natural Science Foundation of China, the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China, the Major Science and Technology Projects in Jiangsu Province, the Natural Science Foundation Outstanding Youth Fund of Jiangsu Province, the Fundamental Research Funds for the Central Universities, the Jiangsu Province High-Level Hospital Construction Funds of Zhongda Hospital, School of Medicine, Southeast University, and the Nanjing U35 Strong Foundation Program
Studies on the molecular structure of GDH show that these mutations are closely related to GTP binding regulatory sites (Table 1)
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