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When to Adjust Your GLP-1 Dose or Explore Personalized Options If fatigue persists beyond 810 weeks despite optimizing nutrition, hydration, and sleep, it may indicate your current dose is suppressing appetite too aggressively for your metabolic needs
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45 In addition to this spleen-mediated mechanism in endotoxaemia, efferent vagus nerve endings might directly regulate the immune function by releasing acetylcholine, without the requirement for either signalling along the splenic nerve or T cells (Figure 1, Figure 2)