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10.1016/j.metabol.2014.02.010 Metabolism 44 YokoiH.YanagitaM

Bempedoic acid was generally well-tolerated following a single oral dose in subjects with renal impairment (Lee et al., 2015), future studies should conclusively demonstrate that the beneficial effects of BA in ADPKD are mediated by AMPK activation and clarify the AMPK subunit involved

The end product of this reaction (AGE), in turn, induce oxidative stress and accelerate the Maillard reactions ultimately leading to inflammation and the propagation of tissue damage [30, 31, 32]

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