If you experience low mood, thoughts of self-harm, or suicidal thoughts, seek urgent medical help contact your GP, call NHS 111, or in an emergency call 999 Patients are encouraged to ask their doctor about the current evidence base, the distinction between trial data and licensed use, and what support will be available if side effects occur
Orforglipron Name: Orforglipron Manufacturer: Eli Lilly Current stage: Expected to submit for regulatory approval by the end of 2025 Takeaway: Less effective than injectables for mean weight loss, but a daily pill could suit some patients better
In parallel, there is growing focus on small molecule GLP-1R agonists , which have the potential to be administered orally, produced more cost-effectively, and offer improved stability and pharmacokinetic profiles
Injection Technique General subcutaneous guidance from clinical best-practice resources [8] [10] [11]