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The antioxidant activity of the Prdx system should be compromised when NADPH cannot be supplied by the pentose phosphate pathway

Beer AM, Wiebelitz KR, Schmidt-Gayk H

A randomized, double-blind, placebo-controlled trial in 153 older adults taking the antidepressant citalopram found daily supplementation with 500 g vitamin B 12 , 2 mg of folic acid, and 25 mg of vitamin B6 for one year did not reduce the severity of depressive symptoms but increased the response to drug treatment and helped to prevent symptom relapse (112), suggesting B-vitamin supplementation might provide some benefit as an adjunct therapy

However, improper administration or excessive use may lead to unnecessary risks like infections or imbalances