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67 A Bayesian network meta-analysis pooled data from 54 RCTs involving 49 602 participants, of whom 28 353 received GLP-1 RA treatment demonstrated that GLP-1 RAs were associated with a reduced risk of fractures compared to placebo or other antihyperglycemic agents

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These include limited long-term safety data across diverse populations, insufficient understanding of mechanisms in neuropsychiatric and oncologic contexts, and suboptimal communication between clinicians and patients

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