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This association was largely explained by a reduced risk of compensated and decompensated cirrhosis (aHR: 0.85), whereas no significant effect was observed for HCC (aHR: 1.05) [60]

Furthermore, counseling on contraception and pregnancy may be needed because of the problems that can occur during pregnancy in patients with diabetes

Following the lead-in period, eligible patients were randomized to 2.5 mg, 5 mg, or 10 mg of saxagliptin or placebo in addition to their current dose of open-label metformin HCl immediate-release (the maximum recommended approved saxagliptin dose is 5 mg daily

10.1038/s41389-017-0021-7 55 KawadaM.InoueH.MasudaT.IkedaD