To account for the pronounced heterogeneity of the preclinical evidence base, specific inclusion criteria for preclinical studies were defined as follows: (1) Model Type: utilization of established in vivo models (e.g., transgenic AD models like APP/PS1 or 3xTg-AD, neurotoxin-induced PD models, middle cerebral artery occlusion for ischemia, or high-fat diet for metabolic dysfunction) or relevant in vitro neuronal/glial cell lines
Our efforts have included in vitro studies, animal studies, pharmacokinetic analyses, and clinical trials
Chicago Dutta, Sanchari Sinha Dutta
Iron is absorbed through the gastrointestinal tract, delivered into the bloodstream, distributed throughout the body, and there are no physiologically routes of excretion after absorption (Fleming and Ponka, 2012)