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Similarly, primary cultures of embryonic rat-derived NSPCs respond to E2 increasing their proliferation ( GPER-1 has been found to be widely expressed in NSPCs (Zhang et al., 2019

It flags that protein as a dangerous enemy

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It should also be noted that there was a protocol deviation in the renal impairment study whereby participants were assigned to renal function groups using an eGFR value expressed in mL/min/1.73 m 2 instead of mL/min