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Furthermore, C18:1-carnitine has been demonstrated to function as an efficacious noncompetitive inhibitor of GlyT2, which has the potential to serve as an analgesic by regulating the transport of glycine in the central nervous system (CNS) and influencing the concentration of this pivotal inhibitory neurotransmitter [112]

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The cumulative effect of these disruptions in both adipokine signaling and lipid metabolism impairs insulin sensitivity, contributing to the progression of T2DM (50)