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The most dramatic improvements Ive seen are in photoaged skin (sun damage), post-inflammatory hyperpigmentation, and overall skin resiliencethe kind of improvements that make you look healthier and more vital rather than just treated. Youre not going to reverse severe deep wrinkles or significant volume loss with GHK-Cu alone, but you will improve the quality of your skin tissue in ways that fillers and lasers cannot

A recent review summarizes safety gaps and the regulatory context in the FDA context

It bulges out

It contains four proline residues (27% of sequence), which impart conformational rigidity that resists proteolytic attack