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Carriers of the GLP1R rs6923761 variant may show enhanced receptor sensitivity, while FTO rs9939609 variants correlate with baseline metabolic rate and weight loss trajectory response

The Diabesity Phenomenon and Its Healthcare Impact Diabesity describes the intertwined pathophysiological relationship between obesity and diabetes, where visceral adiposity leads to insulin resistance

This balance can be disrupted by the inappropriate deposition or misdistribution of metal ions, with the dyshomeostasis of Fe 2+ , Cu 2+ , and Zn 2+ closely associated with AD

The article cites a BMI of 30 or higher, or a BMI of 27 to 29.9 paired with at least one weight-related comorbidity such as type 2 diabetes, hypertension, or cardiovascular disease