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[4] This inquiry largely examined the variations in levels of substance P, beta-endorphin, and corticosteronekey biomarkers relevant for decoding the stress response and the potential regulatory actions of DSIP

While oral bioavailability is lower than subcutaneous administration, these studies established that even high oral doses maintained excellent safety profiles, though higher doses (54 mg) were associated with increased gastrointestinal discomfort

10.1007/s00251-007-0259-x

Interesting most of the literature has focused on fluid during shock resuscitation but maintenance fluid therapy and creep fluid may account for 30% of fluid balance ( Oral water may be harmful in specific subgroup such as acute heart failure, hemorrhage, or digestive ischemia