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In addition to its effects on LDLR as seen here, PCSK9 also downregulates the receptor CD36 which is involved in fatty acid transport and triglyceride storage (Demers et al., 2015), as well as LRP-1 (Canuel et al., 2013), however, the upregulation of both of these has been associated with the progression and metastasis of several different cancers in vitro and in vivo (Deng et al., 2019
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In macrophages, reorganization of the actin cytoskeleton necessary for chemotaxis and phagocytosis requires MsrB1-dependent reduction of methionine-R-sulfoxide residues within actin (27)
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