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Repositioning of diabetes treatments for depressive symptoms: a systematic review and meta-analysis of clinical trials

The tan typically persists 4 to 8 weeks after the last injection, fading gradually as melanocytes turn over

The article's comparison puts osmotic agents such as polyethylene glycol at roughly 12 to 24 hours and describes them as first-line, stimulant agents such as senna at 6 to 12 hours but carrying dependence risk with chronic overuse, stool softeners at 24 to 72 hours with a mild effect best used as an adjunct, and prescription secretagogues at 24 to 48 hours

Retatrutide isn't just another incretin mimetic