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No evidence of cardiac, hepatic, or renal toxicity, changes in serum lipids, or clinically relevant changes in laboratory parameters, vital signs, electrocardiograms, or abnormal findings upon physical examinations have been observed

You would have to take two 1.0mg injections, which is not cost efficacious. In final draft guidance, published on 8 September 2023, the National Institute for Health and Care Excellence (NICE) recommended tirzepatide for the treatment of T2DM, reversing its initial decision against use of the drug in June 2023

Moreover, CNS GIPR KO and mGIPR-Ab/GLP-1 treatment of wild-type mice both result in reduced activity in pathways associated with immune function, particularly neutrophil degranulation, suggesting that decreased CNS GIPR signalling might reduce obesity-associated inflammation 47,48,49