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This is important because many patients with alcohol use disorder (AUD) abuse other substances and suffer from fatty liver and other metabolic abnormalities

Brain-derived neurotrophic factors (BDNF), the most widely distributed neurotrophic factors in the CNS, plays important roles by activating both the prokinetic myosin-associated kinase (Trk) and p75 receptor

Although this seems promising, there is very little evidence supporting topiramates effectiveness, and it does have adverse effects in the brain such as paresthesias (abnormal burning or prickling sensation) [23]

Legette et al., 2014), mimicking endogenous estrogens