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It has been suggested that administration of large amounts or improper combinations of AOXs may lead to shift of the redox balance towards a reductive stress status ( Table 2 ( Table 2 Potential adverse effects of antioxidants

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Its mechanism of action has been attributed to the suppression of proteolytic bacteria, by favoring an increase in acidophilic bacteria (e.g., Lactobacillus) and ammonia ion uptake, thanks to the acidification of the content of the colon (the increase in bowel movement rhythm and osmotic effect due to reduced pH) and bacterial nitrogen metabolism alteration, stimulating the use of ammonia by those bacteria for protein synthesis.47 All those mechanisms explain its efficacy.48,49 A series of randomized clinical trials (RCTs),5053 as well as observational studies, have shown the benefit of lactulose compared with the absence of therapy, albeit there are no truly double-blind studies, given that it is extremely difficult to blind the laxative effect and the typical sweet taste of lactulose

However, nori the kind of seaweed sheet used to wrap sushi has bioavailable B12