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Summary Vitamin E overdose may cause excessive blood thinning and lead to a stroke or an increased risk of death

Despite the early termination of the trial, it is interesting to note that 13 of 140 patients had a median duration of response of 10.2 months, indicating that these patients benefited from combination therapy and that exploring the mechanisms of this benefit should be the focus of future research

Chronic anxiety is debilitating, causing constant worry, nervousness, and tension, significantly impacting daily life and well-being

Novel approaches targeting enterohepatic cycling of bilirubin, such as non-absorbable binding agents, offer promising preventive strategies [10, 39]