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Long-term supplementation is usually required for sustained benefits, particularly in cases of chronic deficiency

The activation of Akt results in skeletal muscle growth/maintenance since it controls the phosphorylation of a number of substrates involved in MPS including mTOR (and its downstream targets 4E-binding protein 1 (4E-BP1) and p70S6 kinase) and glycogen synthase kinase 3 (GSK3), as well as, the inhibition of protein degradation via the forkhead transcription factor (FOXO) pathway (Consitt et al., 2006)

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