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These data support the gene expression data that showed upregulation of CART mRNA in the ARH following semaglutide administration, with simultaneous attenuation of hunger-stimulated increases in NPY and AgRP mRNA levels that were observed in the weight-matched controls

Response: We thank commenters for their helpful feedback regarding future guidance on diagnostic radiopharmaceutical ASP reporting

In contrast to the direct supplementation of L-arginine, which is subject to significant hepatic metabolism, CIT circumvents first-pass degradation and represents a more effective approach for enhancing systemic L-arginine levels and the bioavailability of NO

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