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We propose that in the absence of a peptide, the ECD is dynamic but favors a closed conformation stabilized by the weak interactions between the ECD and ECL1/3

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p53 is nicknamed the guardian of the genome because it is a tumor supressor when it detects mutation in the cells DNA (which can turn the cell into cancer), it causes apoptosis (in fact, lots of cancers are associated with genetic mutations that switch off p53, meaning that p53 stops working and cant kill the cell before it forms a tumor and possibly becomes cancerous)