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Since Sikiric et al 47 firstly demonstrated that NO generation in gastric mucosa contributes to the anti-ulcer effect of BPC 157 in gastric lesion, subsequently, several reports analyzed the role of NO modulation in the healing effect of BPC 157 in different tissue injuries by using NO-synthase-blockade L-NAME or NO-system overstimulation L-arginine
Notably, LCA has been found to activate Taste Receptor Type 2 Member 1 (TAS2R1) in humans at a concentration of 0.3 M, while TLCA activates TAS2R1, TAS2R14, and TAS2R46 at the same concentration
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