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Plasma iron concentrations are maintained at a low level (as complexes with transferrin), and this decreases substantially during the acute phase response to infection or other inflammatory stimuli (Ganz, 2018

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This is the better choice for joint inflammation, whole-body inflammatory conditions, or any target outside the digestive system

Notably, despite the positive effects on renal outcomes, the study also reported an increased incidence of gastrointestinal side effects, including nausea, vomiting, and diarrhea, though these were not statistically significant [89]