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Similarly, compounds from the spiro-oxindole dihydroquinazolinone series identified in the screening, e.g., 42 are weak inhibitors and besides that not stable in in vitro assays

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PMID: 29986520 Tertiary SOD / Anti-Inflammatory Copper-Dependent Enzyme Activation As a bioavailable copper delivery system, GHK-Cu supports the activity of copper-dependent enzymes including superoxide dismutase (SOD), cytochrome c oxidase, and lysyl oxidase