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As we observe a correlation between SPHKAP variant effects in T2D and high BMI (as a proxy for obesity), we propose here that SPHKAP might play a pleiotropic role in both disorders by the engagement of common signalling pathways in different tissues

If appetite control weakens or weight loss stops completely after working initially, several factors might explain this

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Busingye D, Pollack A, Chidwick K