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Some dont even know they have them because they feel normal

Glucagon-like peptide-1 (GLP-1) receptor agonists function like the incretin hormone GLP-1 that is released into the intestine after consumption of food

(PubMed) Henkin RI, Patten BM, Re PK, Bronzert DA

Regarding the central mechanism of feeding regulation, proopiomelanocortin (POMC) neurons in the arcuate nucleus (ARC) of the hypothalamus are key anorexigenic neurons