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The following procedure was performed at T1 and T2 for assessment of biomarker levels and mandibular length

Liraglutide activates the PKA/CREB pathway in the cartilage tissues of the knee OA rat model Western blot analysis was also used to detect the expression of PKA/CREB pathway components in the cartilage tissues of OA knees after treatment with liraglutide or saline

Chronic cases may require a full 12-week cycle and occasionally a second cycle after a break to reach the target endpoint

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