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Such observations have also been seen in human liver cirrhosis [20]

Emerging evidence indicates that neuroinflammation and excessive microglial activity are involved in the pathogenesis of depression [67]

The PLD2-mediated low-level ROS generation by receptor-internalizing or endogenous opioids might be one reason for a lower neurotoxicity compared with noninternalizing opioids under physiologic conditions and this might have implications for analgesic therapy