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The FDA-approved Wegovy label, for example, describes semaglutide as a GLP-1 receptor agonist used with reduced calories and increased physical activity for long-term weight reduction in certain adults and adolescents, and for reducing risk of major cardiovascular events in certain adults with cardiovascular disease and overweight or obesity

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The gut microbiome composition associates with bipolar disorder and illness severity

astrocytes in the grey matter lose ~ 50% of their perivascular endfeet