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Furosemide Class * Loop diuretic Mechanism of Action Furosemide inhibits the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle, causing: * Increased excretion of sodium and water * Increased excretion of potassium, calcium, and magnesium * Rapid reduction of fluid overload Indications * Acute pulmonary edema * Congestive heart failure * Hypertension (especially with edema) * Chronic kidney disease with fluid overload * Nephrotic syndrome * Liver cirrhosis with edema * Hypercalcemia (with adequate hydration) Dosage Adults * Oral: 2080 mg daily, adjusted according to response * IV: 2040 mg initially