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of four RCTs with 176 participants demonstrated that GLP1-RAs significantly reduced waist circumference (MD: 5.16 cm), BMI (MD: 2.42 kg/m 2 ), serum triglycerides (MD: 0.20), and total testosterone levels (MD: 1.33) compared to placebo [129]

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Similarly, exposure to methylglyoxal, a reactive dicarbonyl compound formed as a metabolic byproduct of glycolysis, has been shown to inhibit glycolysis, leading to a reduction in ATP and GSH concentrations

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