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10.3748/wjg.v23.i33.6016 16 FitzpatrickL

Severe symptomatic hypoglycemia was defined as an event with symptoms consistent with hypoglycemia requiring the assistance of another person and associated with either a blood glucose below 50 mg/dL (56 mg/dL in the 5-year study and 36 mg/dL in the ORIGIN study) or prompt recovery after oral carbohydrate, intravenous glucose, or glucagon administration

Which would be consistent with the known profiles of GLP-1 receptor agonists

KPV's mechanism of action (NF-kB inhibition) overlaps with some conventional autoimmune drugs, particularly corticosteroids and JAK inhibitors, which also suppress NF-kB-mediated inflammation