There is strong evidence to support that creatine supplementation improves mood and depression, particularly in women
Int J Biol Sci (2021) 17(8):205068
Ingredients: inulin powder, prickly pear (nopal) stem extract 10:1 (Opuntia ficus-indica), mango flavor, lemon flavor, valerian (Valeriana officinalis, root) extract, stabiliser: cellulose, Rebersa Hydrochloride (Berberis aristata extract) of which 97% berberine chloride, turmeric (Curcuma longa, root) extract, cinnamon (Cinnamomum zeylanicum, bark) powder, sweetener: steviol glycosides from stevia, chromium picolinate
They got weekly injections of either Ozempic or placebo for 68 weeks, tracking two main outcomes: body weight and pain (WOMAC pain score, a well-established scoring system for knee osteoarthritis)